Red Sox - 100 100 001 - 3 7 0 Mariners - 010 610 40x - 12 14 1John Lackey (3.2-7-7-2-3, 74) imploded in the fourth, facing nine batters and throwing 38 pitches. The big blow was Endy Chavez's three-run triple.
David Ortiz's drove in Boston's first run with a two-out single through the shift. Mike Napoli homered in the fourth, giving the Red Sox a brief 2-1 lead. A.J. Pierzynski added a sac fly in the ninth.
Ortiz, Napoli, and Dustin Pedroia each had two hits.