Carlos Pena won the game with a solo home run to right (his first long ball of the year) leading off the bottom of the 10th against Brandon McCarthy.
The Red Sox had tied the game at 2-2 in the bottom of the ninth when Manny Ramirez walked and scored on Mike Lowell's double.
Sexy Lips's nice start (6.1-6-2-0-5) was not wasted.
Jon Garland (4.47) / Julian Tavarez (4.90), 7 PM
Manny, Varitek and Nixon are back. Youkilis is back at the leadoff spot and Hinske (DH) is batting third.